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Advise sufferers that: Tramadol Hydrochloride Prolonged-Release is for oral use only and may be swallowed full. The capsule shouldn't be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Extended-Release may bring about seizures and/or serotonin syndrome with concomitant use of serotonergic brokers (such as SRIs, NRIs, and triptans) or